Global orphan prescription drug revenues 2016-2028

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This statistic shows the worldwide revenue generated through prescription orphan drugs from 2016 to 2028. In 2022, orphan drugs revenues totaled 156 billion U.S. dollars. Orphan drugs are used to target rare diseases or disorders, which in the United States is defined as less than 200,000 patients. The development of orphan drugs are currently incentivized in the United States through the Orphan Drug Act of 1983.

Global prescription orphan drug sales from 2016 to 2028 (in billion U.S. dollars)

Characteristic	Revenue in billion U.S. dollars
2028	300
2027	273
2026	244
2025	220
2024	195
2023*	173
2022	156
2021	148
2020	130
2019	113
2018	102
2016	91

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Release date

March 2023

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Region

Worldwide

Survey time period

2016 to 2023

Supplementary notes

Products that have orphan and non-orphan drug designations and are expected to generate less than 50% of their sales from their orphan-designated indication/s, are excluded from this statistic. This has led to the exclusion of therapies such as Avastin, Opdivo, Enbrel, Herceptin, Humira and Remicade.
* From 2023 on projected.

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